Distinct from Methotrexate and Leflunomide Arthritis by Blocking IL-17 Signaling, Drug, Iguratimod, Ameliorates Murine A Novel Disease-Modifying Antirheumatic

نویسندگان

  • Xu Feifei Tao
  • Yanhong Gu
  • Xingxin Wu
  • Yan Shen
  • Qiong Luo
  • Yang Sun
  • Wen Liu
  • Cheng Qian
  • Biao Jin
  • Feifei Tao
  • Qiang Xu
چکیده

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A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide.

Iguratimod, a novel disease-modifying antirheumatic drug, which is now used in clinics in China and Japan, has been confirmed as a highly efficacious and safe drug for rheumatoid arthritis therapy. The antiarthritic mechanism of iguratimod, especially compared with that of the classical disease-modifying antirheumatic drugs, has not been elucidated. In this study, we conducted a comparative ana...

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تاریخ انتشار 2013